JERSEY CITY, N.J., May 21, 2024 /PRNewswire/ — InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the “Global Next Generation Drug Conjugates Market – By Type (Peptide Receptor Radionuclide Therapy, Ligand mediated RNAi Conjugate, Ligand Conjugated Anti Sense Medicine and Peptide Drug Conjugate), By Type of Targeting Ligand (Amino Sugar, Peptide, Lipid, Small Molecule and Virus-like Particles), By Type of Payload (Peptide, Small Molecule, Oligonucleotide, Radionuclide), By Type of Therapy (Monotherapy, Combination Therapy), By Route of Administration, By Target Indications, By Region, Trends, Industry Competition Analysis, Revenue and Forecast To 2031.”

According to the latest research by InsightAce Analytic, the Global Next Generation Drug Conjugates Market is valued at US$ 2.61 Bn in 2023, and it is expected to reach US$ 7.94 Bn by 2031, with a CAGR of 15.1% during the forecast period of 2024-2031.

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Next Generation Drug Conjugates Market Report Scope:

Growth of the next-generation drug conjugates market is driven by several factors, such as the recent accelerated approvals of various next-generation drug conjugates and the keen interest shown by the big pharma players in forging strategic alliances with the next-generation drug conjugate developers.

The ever-growing rise in medicare costs, along with the increasing burden of rare disease indications, prompted the stakeholders to look for alternatives to conventional therapies. As a result, the next-generation conjugates combine cytotoxic drugs with targeting agents, enhancing drug efficacy while reducing systemic toxicity. Deeper cellular penetration and permeability have emerged as viable targeted therapeutics for rare disease indications, including cancers.

List of Prominent Players in the Next Generation Drug Conjugates Market:

• Advanced Accelerator Applications
• Alnylam Pharmaceuticals
• Arrowhead Pharmaceuticals
• Dicerna Pharmaceuticals
• Geron Corporation
• Ionis Pharmaceuticals
• Dyne Therapeutics, Inc.
• Ambrx Biopharma, Inc. (Johnson & Johnson Services, Inc.)
• Vincerx Pharma
• Tubulis Technologies
• Nurix Therapeutics, Inc.
• Other Prominent Players

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Market Dynamics:

Drivers:

The growth of the next generation drug conjugates (NGDCs) market is driven by several key factors. Technological advancements, such as improved linker technologies and versatile applications, enhance drug efficacy and safety.

The rising prevalence of chronic diseases, particularly cancer and genetic disorders, fuels demand for targeted therapies. Strategic industry collaborations and acquisitions, like Pfizer’s purchase of Seagen, accelerate innovation and market expansion. Favorable regulatory environments support expedited review processes and clear development guidelines. Additionally, significant investment in research and development, supported by funding and innovative platforms, drives the discovery and optimization of new NGDCs. These combined factors contribute to the rapid advancement and adoption of NGDCs in modern medicine.

Challenges:

The global next-generation drug conjugates market faces several formidable challenges. One of the primary obstacles is the high development cost associated with these therapies. The complex manufacturing processes required for drug conjugates involve sophisticated technology and stringent quality control measures, making scalability difficult and expensive. Additionally, the regulatory landscape presents significant hurdles; furthermore, gaining permission from regulatory bodies like the FDA and EMA is a time-consuming and expensive process that frequently necessitates substantial clinical trials to prove safety and efficacy.

Another major challenge is ensuring the stability and efficacy of drug conjugates. In order to be effective, these therapies must both release the therapeutic agent at the target site in a controlled manner and be stable under physiological conditions. Balancing these requirements while minimizing toxicity is a complex scientific and technical task. Patents and proprietary technology can restrict the capacity of new companies to enter the market and innovate, which further complicates intellectual property issues.

Regional Trends:

The North American next generation drug conjugates market is growing due to advanced healthcare infrastructure and significant R&D investments. Key players in the region are driving innovation in targeted cancer therapies, leveraging cutting-edge technologies for drug conjugation. The increasing cases of cancer and the rising demand for personalized medicine boost the market. Favorable regulatory policies further stimulate market growth, allowing swift approval and commercialization of novel drug conjugates.

Moreover, strategic collaborations between pharmaceutical companies and research institutions fuel the development of next-generation therapies. With a robust pipeline and expanding applications beyond oncology, the North American market for drug conjugates is poised for sustained expansion.

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Recent Developments:

• In April 2023, Novartis entered into a licensing agreement with 3B Pharmaceuticals. 3B Pharmaceuticals is a German-based company involved in the growth of peptide receptor radionuclide therapy (PRRT) candidates targeting fibroblast activation protein (FAP) receptors.
• In March 2023, Japan-based PeptiDream signed strategic partnership with US-based RayzeBio to develop a peptide-radioisotope (RI) conjugate against Glypican-3 (“GPC3”) expressed in liver cancers.
• In March 2023, The USFDA accepted Ionis Pharmaceutical’s New Drug Application (NDA) for its investigational antisense medication Eplontersen, which is intended for patients with hereditary transthyretin-mediated amyloid polyneuropathy (ATTRv-PN). After Amvuttra (vutrisiran) from Alnylam, Eplontersen will be the second medication licensed for the treatment of hereditary transthyretin-mediated amyloid polyneuropathy (ATTRv-PN).

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Segmentation of Next Generation Drug Conjugates Market-

Next Generation Drug Conjugates Market- By Type

• Peptide Receptor Radionuclide Therapy (Peptide Radionuclide Conjugate)
• Ligand-mediated RNAi Conjugate
• Ligand Conjugated Antisense Medicine
• Peptide Drug Conjugate

Next Generation Drug Conjugates Market- By Targeting Ligand

• Amino Sugar
• Lipid
• Peptide
• Small Molecule
• Virus-like Particles

Next Generation Drug Conjugates Market- By Payload

• Peptide
• Small Molecule
• Oligonucleotide
• Radionuclide

Next Generation Drug Conjugates Market- By Therapy

• Monotherapy
• Combination Therapy

Next Generation Drug Conjugates Market- By Route of Administration

• Intravenous
• Subcutaneous
• Others

Next Generation Drug Conjugates Market- By Indications

• Gastroenteropancreatic Neuroendocrine Tumors
• Prostate Cancer
• Leptomeningeal Carcinomatosis caused by Breast Cancer Brain Metastases
• Hereditary Transthyretin Amyloidosis
• Atherosclerotic Cardiovascular Diseases
• Severe Hypertriglyceridemia
• Hereditary Angioedema
• Acute Hepatic Porphyria
• Primary Hyperoxaluria
• Heterozygous Familial Hypercholesterolemia
• Hemophilia
• Low-Risk Myelodysplastic Syndrome
• Myelofibrosis
• Familial Chylomicronemia Syndrome
• Alpha-1 Antitrypsin Deficiency Liver Disease

Next Generation Drug Conjugates Market- By Region

North America–

• The US
• Canada
• Mexico

Europe–

• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe

Asia-Pacific–

• China
• Japan
• India
• South Korea
• South East Asia
• Rest of Asia Pacific

Latin America–

• Brazil
• Argentina
• Rest of Latin America

 Middle East & Africa–

• GCC Countries
• South Africa
• Rest of Middle East and Africa

Why should buy this report:

• To receive a comprehensive analysis of the prospects for global next generation drug conjugates market
• To receive industry overview and future trends of global next generation drug conjugates market
• To analyze the next generation drug conjugates market drivers and challenges
• To get information on the next generation drug conjugates market size value (US$ Mn) forecast till 2031
• Major Investments, Mergers & Acquisition in global next generation drug conjugates market industry

Other Related Reports Published by InsightAce Analytic:

Antibody Drug Conjugates (ADCs) – Linker and Conjugation Technologies Market 

Conjugation and Labeling Services Market 

Peptide–Drug Conjugates (PDCs) Market

Antibody Discovery Market

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